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March 23, 2026
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Possible Mechanisms by Which ADAMs Influence Integrin-mediated Cell Migration
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CHO-α4/GFP cells were transfected with 4 μg of DNA (per 6-cm dish) encoding the indicated 6Xmyc-tagged constructs. Expression of wild-type and mutant full-length ADAMs on the surface of CHO-α4/GFP cells. Average wound closure for cells transfected with different ADAM12 constructs was expressed as a percentage of that seen for mock-transfected cells. A similar observation with the D488A mutant was obtained using CHOB2-α4 cells in adhesion flow assays.